Why the study?
Doxorubicin causes destructive hepatic toxicity, requiring antioxidant coadministration to reduce its toxic effects, prompting investigation into the protective capacity of combined vitamin E and omega-3.
Does co-administration of Vitamin E and Omega-3 reduce doxorubicin-induced hepatotoxicity in mice?
Population
Thirty balb/c mice weighing 25 g
Comparison
Vitamin E plus omega-3 plus DOX vs DOX alone, vitamin E plus DOX, omega-3 plus DOX, and control
Design
Animal experimental study
Authors
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May reduce doxorubicin hepatotoxicity in mice; leaves open translation to human oncology practice.
Does co-administration of Vitamin E and Omega-3 reduce doxorubicin-induced hepatotoxicity in mice?
Co-administration of Vitamin E and Omega-3 may offer protective effects against doxorubicin-induced hepatotoxicity in a mouse model.
Lotfi et al. (2022) studied this question.
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