Key result
Omega-3 supplementation significantly reduced the incidence of doxorubicin-induced kidney tubular dilatation from 80% to 30% and attenuated systemic genotoxicity and serum markers of kidney damage.
Why the study?
Doxorubicin is an effective chemotherapeutic agent limited by cardio-, nephro-, and hepatotoxicity, prompting investigation of protective strategies such as omega-3 supplementation.
Does omega-3 supplementation prevent doxorubicin-induced hepatotoxicity and nephrotoxicity in male Wistar rats?
Population
Male Wistar rats (10 rats/group)
Comparison
Omega-3 supplementation plus doxorubicin vs doxorubicin alone
Design
Preclinical animal study
Follow-up
Six weeks
Authors
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ω-3 may attenuate DOX organ toxicity in animals; leaves open translation to human cardioprotection.
Does omega-3 supplementation prevent doxorubicin-induced hepatotoxicity and nephrotoxicity in male Wistar rats?
Absolute Event Rate: 30% vs 80%
Absolute Risk Reduction: 50%
p-value: p=<0.001
In a rat model, omega-3 supplementation attenuated doxorubicin-induced deleterious effects on the liver and kidneys, suggesting potential for future clinical interventions.
Santo et al. (2023) studied Doxorubicin-induced hepatotoxicity and nephrotoxicity (n=40). Omega-3 vs. Vehicle was evaluated on Incidence of kidney tubular dilatation (p=<0.001). Omega-3 supplementation significantly reduced the incidence of doxorubicin-induced kidney tubular dilatation from 80% to 30% and attenuated systemic genotoxicity and serum markers of kidney damage.
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