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June 1, 2010Journal of International Medical Research

The Beneficial Effect of n -3 Polyunsaturated Fatty Acids on Doxorubicin-induced Chronic Heart Failure in Rats

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Key result

Dietary supplementation with n-3 PUFA attenuated doxorubicin-induced cardiac dysfunction and cytokine imbalance in rats.

Why the study?

Does n-3 PUFA supplementation improve cardiac function in a rat model of doxorubicin-induced chronic heart failure?

Population

Male Sprague-Dawley rats with doxorubicin-induced chronic heart failure

Comparison

n-3 polyunsaturated fatty acids from fish oil… vs Normal saline administered intragastrically…

Design

Preclinical

Follow-up

8 weeks

Authors

LTLL TengZYZhao YtXYX Yu

Discussion

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Member takes

Overview

Hypothesis-generating for n-3 PUFA in doxorubicin cardiotoxicity; human trials needed before any clinical consideration.

Structured PICO

Does n-3 PUFA supplementation improve cardiac function in a rat model of doxorubicin-induced chronic heart failure?

P
Population
Male Sprague-Dawley rats with doxorubicin-induced chronic heart failure treated for 8 weeks.
I
Intervention
n-3 polyunsaturated fatty acids (PUFA) from fish oil administered intragastrically daily for 8 weeks
C
Comparator
Normal saline administered intragastrically daily for 8 weeks
O
Outcome
Cardiac function assessed by echocardiographysurrogate

In a rat model, n-3 PUFA supplementation attenuated doxorubicin-induced heart failure and myocardial injury, potentially through modulation of the cytokine network.

Cite This Study

Teng et al. (2010) studied Doxorubicin-induced chronic heart failure. n-3 polyunsaturated fatty acids (PUFA) vs. normal saline was evaluated on Cardiac function by echocardiography, histological damage, and serum cytokines. Dietary supplementation with n-3 PUFA attenuated doxorubicin-induced cardiac dysfunction and cytokine imbalance in rats.

synapsesocial.com/papers/6a9192e5388f32339cd2daf2https://doi.org/10.1177/147323001003800320
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Also Consider

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  1. 1Inflammatory and anti‐inflammatory cytokines in chronic heart failure: Potential therapeutic implications2005 · 165 citations
  2. 2Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005)2005 · 2,269 citations
  3. 3Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials2002 · 701 citations
  4. 4Eicosapentaenoic Acid Prevents LPS-Induced TNF-α Expression by Preventing NF-κB Activation2004 · 405 citations