What is the clinical evidence from this study?

Population: Doxorubicin-induced nephrotoxicity (n=35). Intervention: Ceratonia siliqua methanol extract vs. Doxorubicin alone. Primary outcome: Serum creatinine (mg/dl) (p=0.001).

June 21, 2023Environmental Science and Pollution ResearchOpen Access

Ceratonia siliqua pods (Carob) methanol extract alleviates doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory and anti-apoptotic pathways in rats

Q: What does this research mean for the field?

Ceratonia siliqua methanol extract significantly reduces serum creatinine and alleviates doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory, and anti-apoptotic pathways in rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Ceratonia siliqua extract reduces serum creatinine ~24% and alleviates doxorubicin-induced nephrotoxicity in rats.

P=0.001
n=35

Why the study?

Doxorubicin is an effective anti-neoplastic therapy, but its clinical utility is limited by deleterious toxic effects including nephrotoxicity and cardiotoxicity.

Does Ceratonia siliqua methanol extract prevent doxorubicin-induced nephrotoxicity in rats?

Population

5 groups of Wistar rats

Comparison

Ceratonia siliqua methanol extract treatment vs DOX-induced nephrotoxicity

Design

Animal experimental study

Authors

AAAttia H. AttaAin Shams University SAShimaa AttaTheodor Bilharz Research Institute MKMarwa S. KhattabCairo University

Discussion

Member takes

Implication

Should not yet change practice for doxorubicin nephrotoxicity; leaves open hypothesis-generating potential for Ceratonia siliqua in translational renoprotection research.

Structured PICO

Does Ceratonia siliqua methanol extract prevent doxorubicin-induced nephrotoxicity in rats?

Population

35 Wistar rats weighing 200-250g with doxorubicin-induced nephrotoxicity treated for 5 days.

Intervention

Ceratonia siliqua methanol extract (CME) at 500 or 1000 mg/kg orally for 5 days, followed by doxorubicin 15 mg/kg intraperitoneally.

Comparator

Doxorubicin alone (15 mg/kg intraperitoneally) and normal saline control.

Outcome

Nephrotoxicity assessed by serum kidney function parameters (creatinine, urea, electrolytes), oxidative stress markers, inflammatory cytokines, apoptotic markers, and histopathology at 48 hours post-doxorubicin.surrogate

Main Result

Absolute Event Rate: 0.52% vs 0.68%

p-value: p=0.001

Ceratonia siliqua methanol extract effectively alleviates doxorubicin-induced nephrotoxicity in rats via antioxidant, anti-inflammatory, and anti-apoptotic pathways.

Limitations

Study was carried out on laboratory animals using an experimental model, so results cannot be drawn directly into clinical practice.
Isolation and revaluation of the active constituents of the plant material are needed.

Cite This Study

Atta et al. (2023) studied Doxorubicin-induced nephrotoxicity (n=35). Ceratonia siliqua methanol extract vs. Doxorubicin alone was evaluated on Serum creatinine (mg/dl) (p=0.001). Ceratonia siliqua methanol extract significantly reduced serum creatinine and alleviated doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory, and anti-apoptotic pathways in rats.

synapsesocial.com/papers/6a23bfaca98279854dd35f8a https://doi.org/10.1007/s11356-023-28146-z

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Implication

Should not yet change practice for doxorubicin nephrotoxicity; leaves open hypothesis-generating potential for Ceratonia siliqua in translational renoprotection research.

Ceratonia siliqua pods (Carob) methanol extract alleviates doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory and anti-apoptotic pathways in rats

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Ceratonia siliqua pods (Carob) methanol extract alleviates doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory and anti-apoptotic pathways in rats

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider