December 5, 2025AntioxidantsOpen Access

Cistanche deserticola Polysaccharides Protect Against Doxorubicin-Induced Cardiotoxicity via Antioxidant and Mitochondrial Mechanisms

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Observational analysis in C57BL/6J mice showed doxorubicin cardiotoxicity reduced by antioxidants, suggesting a potential protective mechanism.

Doxorubicin cardiotoxicity improved cardiac function and antioxidant levels in C57BL/6J mice, revealing treatment potency.
The reduction of oxidative stress markers like malondialdehyde and increased levels of superoxide dismutase highlights efficacy.
Assessment of mitochondrial function using adenosine triphosphate levels indicates beneficial outcomes from Cistanche deserticola administration.
These findings support the potential for Cistanche deserticola polysaccharides in managing doxorubicin-related heart damage.

Qi et al. (2025) studied this question.

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Observational analysis in C57BL/6J mice showed doxorubicin cardiotoxicity reduced by antioxidants, suggesting a potential protective mechanism.