Key result
Centaurea castriferrei extracts significantly abolished the cytotoxic effect and reduced oxidative stress caused by doxorubicin in H9c2 cells without affecting its cytotoxicity on MCF-7 cells.
Why the study?
Doxorubicin use is limited by dose-dependent cardiotoxicity driven largely by oxidative stress, prompting evaluation of cardioprotective adjuvants.
Does Centaurea castriferrei extract prevent doxorubicin-induced cardiotoxicity in H9c2 cells?
Population
Rat embryonic cardiomyocyte cell line H9c2 and MCF-7 breast cancer cell line
Comparison
DOX plus Centaurea castriferrei water or methanol-water extracts vs DOX alone
Design
In vitro controlled laboratory study
Follow-up
48 h
Authors
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These in vitro findings support further preclinical testing of Centaurea extracts; leaves open translation to in vivo or clinical cardioprotection.
Does Centaurea castriferrei extract prevent doxorubicin-induced cardiotoxicity in H9c2 cells?
Centaurea castriferrei extracts show potential as cardioprotective adjuvants against doxorubicin-induced cardiotoxicity in vitro by reducing oxidative stress.
Humeniuk et al. (2023) studied Doxorubicin-induced cardiotoxicity. Centaurea castriferrei (CAS) water and methanol-water extracts vs. Doxorubicin alone was evaluated on Cytotoxic effect and oxidative stress levels. Centaurea castriferrei extracts significantly abolished the cytotoxic effect and reduced oxidative stress caused by doxorubicin in H9c2 cells without affecting its cytotoxicity on MCF-7 cells.
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