Key result
Galium verum extract prevents doxorubicin-induced cardiotoxicity in rats by reducing oxidative stress and apoptosis.
Why the study?
This study aimed to examine the effects of a 14-day treatment with lady's bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical, and histological examinations.
Does Galium verum extract prevent doxorubicin-induced cardiotoxicity in a rat model?
Does Galium verum extract prevent doxorubicin-induced cardiotoxicity in a rat model?
Lady's bedstraw extract shows potential as a protective agent against doxorubicin-induced cardiotoxicity in a preclinical rat model by reducing oxidative stress and apoptosis.
This study aimed to examine the effects of a 14-day treatment with lady’s bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 male Wistar albino rats divided into the following groups: control (CTRL), doxorubicin (DOX), and DOX + GVE (Galium verum extract). GVE was administered orally at a dose of 50 mg/kg per day for 14 days, while a single dose of doxorubicin was injected into the DOX groups. After accomplishing treatment with GVE, cardiac function was assessed, which determined the redox state. During the autoregulation protocol on the Langendorff apparatus, ex vivo cardiodynamic parameters were measured. Our results demonstrated that the consumption of GVE effectively suppressed the disturbed response of the heart to changes in perfusion pressures caused by administration of DOX. Intake of GVE was associated with a reduction in most of the measured prooxidants in comparison to the DOX group. Moreover, this extract was capable of increasing the activity of the antioxidant defense system. Morphometric analyses showed that rat hearts treated with DOX showed more pronounced degenerative changes and necrosis compared to the CTRL group. However, GVE pretreatment seems to be able to prevent the pathological injuries caused by DOX injection via decrease in oxidative stress and apoptosis.
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Bradić et al. (2023) studied Doxorubicin-induced cardiotoxicity (n=24). Galium verum extract (GVE) vs. Doxorubicin alone and control was evaluated on Cardiac function, redox state, and histological changes. A 14-day treatment with Galium verum extract (50 mg/kg/day) prevented doxorubicin-induced cardiotoxicity in rats by decreasing oxidative stress and apoptosis.
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