Active smoking (OR 21.48; 95% CI 8.80-52.41) and other modifiable risk factors significantly increased the risk of having a first acute stroke at age 75 years or younger.
Cross-Sectional (n=436)
No
What is the effect of modifiable risk factors on the age at which a first stroke occurs?
Modifiable risk factors such as smoking, sedentary lifestyle, alcohol consumption, and obesity are strongly associated with experiencing a first stroke at an earlier age (≤75 years).
Odds Ratio: 21.48 (95% CI 8.8–52.41)
(1) Background: Stroke is a multifactorial disease, which can affect individuals at any age. Risk factors (RFs) associated with the first stroke event have been well identified; however, the influence of these RFs on the patient´s age needs to be studied. (2) Objective: This study aimed to examine the effect of modifiable RFs on the age at which a stroke occurs. (3) Methods: A cross-sectional study was conducted on patients admitted consecutively with a first-ever acute stroke at the Burgos University Hospital (Spain). Data on sociodemographic and clinical parameters were collected (high blood pressure (HBP), smoking habit, diabetes mellitus (DM), dyslipemia, abdominal obesity, sedentary lifestyle, alcohol consumption, and cardiovascular diseases). The possible associations between RFs and age were studied using univariate and multivariate regression analyses and a decision tree. (4) Results: A total of 436 patients with a mean age of 75.39 years (standard deviation (SD) ± 12.67) were included. HBP and overweight/obesity were the most prevalent stroke RFs. Being an active smoker (OR 21.48; 95% confidence interval (CI) 8.80-52.41), having a sedentary lifestyle (OR 3.24; 95% CI 1.97-5.31), being an excessive alcohol drinker (OR 2.36; 95% CI 1.45-3.84), or being overweight or obese (OR 1.95; 95% CI 1.14-3.34) increased the risk of having an acute cerebrovascular event in individuals aged 75 years or below. However, a personal history of HBP (OR 0.40; 95% CI 0.24-0.67) was significantly associated with a greater likelihood of having an acute stroke in individuals aged more than 75 years. (5) Conclusions: This study showed that the modifiable RFs strongly influence the first stroke event in patients aged below 75 years, which will be useful in guiding different prevention strategies.
Soto‐Cámara et al. (Tue,) conducted a cross-sectional in first-ever acute stroke (n=436). Active smoking vs. Non-smokers was evaluated on First stroke event occurring at age 75 years or below (OR 21.48, 95% CI 8.80-52.41). Active smoking (OR 21.48; 95% CI 8.80-52.41) and other modifiable risk factors significantly increased the risk of having a first acute stroke at age 75 years or younger.
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