Key result
Active smoking linked to ~21.5-fold higher odds of first acute stroke at age <=75.
Why the study?
While risk factors associated with a first stroke event are well identified, their influence on the patient's age at which stroke occurs needs to be studied.
Does an active smoking habit influence the age at which a first-ever acute stroke occurs in adults?
Cross-Sectional (n=436)
No
Does an active smoking habit influence the age at which a first-ever acute stroke occurs in adults?
Answers are grounded in this paper and cite their sources.
Modifiable lifestyle risk factors, particularly active smoking and physical inactivity, are strongly associated with a significantly earlier onset of first-ever acute stroke, underscoring the importance of early targeted primary prevention.
(1) Background: Stroke is a multifactorial disease, which can affect individuals at any age. Risk factors (RFs) associated with the first stroke event have been well identified; however, the influence of these RFs on the patient´s age needs to be studied. (2) Objective: This study aimed to examine the effect of modifiable RFs on the age at which a stroke occurs. (3) Methods: A cross-sectional study was conducted on patients admitted consecutively with a first-ever acute stroke at the Burgos University Hospital (Spain). Data on sociodemographic and clinical parameters were collected (high blood pressure (HBP), smoking habit, diabetes mellitus (DM), dyslipemia, abdominal obesity, sedentary lifestyle, alcohol consumption, and cardiovascular diseases). The possible associations between RFs and age were studied using univariate and multivariate regression analyses and a decision tree. (4) Results: A total of 436 patients with a mean age of 75.39 years (standard deviation (SD) ± 12.67) were included. HBP and overweight/obesity were the most prevalent stroke RFs. Being an active smoker (OR 21.48; 95% confidence interval (CI) 8.80-52.41), having a sedentary lifestyle (OR 3.24; 95% CI 1.97-5.31), being an excessive alcohol drinker (OR 2.36; 95% CI 1.45-3.84), or being overweight or obese (OR 1.95; 95% CI 1.14-3.34) increased the risk of having an acute cerebrovascular event in individuals aged 75 years or below. However, a personal history of HBP (OR 0.40; 95% CI 0.24-0.67) was significantly associated with a greater likelihood of having an acute stroke in individuals aged more than 75 years. (5) Conclusions: This study showed that the modifiable RFs strongly influence the first stroke event in patients aged below 75 years, which will be useful in guiding different prevention strategies.
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Soto‐Cámara et al. (2020) conducted a cross-sectional in First-ever acute stroke (n=436). Active smoking habit vs. Non-smokers was evaluated on Occurrence of acute cerebrovascular event at age 75 years or below (OR 21.48, 95% CI 8.80-52.41). Being an active smoker significantly increased the odds of experiencing a first-ever acute stroke at age 75 years or younger by more than 21-fold compared to non-smokers.
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