July 1, 2020Open Access
Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement
Structured PICO
Do different flow-gradient patterns of aortic stenosis affect clinical outcomes after aortic valve replacement?
P
Population
Patients with aortic stenosis undergoing aortic valve replacement from the PARTNER 2 trial and registry
I
Intervention
Low-gradient (LG) aortic stenosis patterns, including classical low-flow low-gradient (CLF-LG) and LG with preserved left ventricular ejection fraction
C
Comparator
High-gradient (HG) aortic stenosis
O
Outcome
Composite of death, rehospitalization, or stroke at 2 yearscomposite
Following aortic valve replacement, patients with classical low-flow, low-gradient aortic stenosis have worse 2-year outcomes compared to those with high-gradient AS, while those with low-gradient AS and preserved LVEF have comparable outcomes.
Abstract
The LG AS pattern was highly prevalent (36.5%) in the PARTNER 2 trial and registry. CLF-LG was the most common pattern of LG AS and was associated with higher rates of death, rehospitalization, or stroke at 2 years compared with the HG group. Clinical outcomes were as good in the LG AS groups with preserved left ventricular ejection fraction compared with the HG group.
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Authors
E
Erwan Salaün
Centre National de la Recherche Scientifique
M
Marie‐Annick Clavel
Structural Heart Disease
Rebecca T. Hahn
Structural Heart Disease
Journals
Circulation Cardiovascular Interventions
Actions
Institutions
Stanford University
University of Pennsylvania
Duke Medical Center
References and Citations
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