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Multiomics profiling of ovarian tumor samples pre- and post-NACT provides unique insight into chemo-induced changes to the tumor microenvironment. We identified a novel IL6/IER3 signaling axis that may drive chemoresistance and disease recurrence.
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Kimberly R. Jordan
University of Colorado Anschutz Medical Campus
Matthew J. Sikora
University of Colorado Anschutz Medical Campus
Jill E. Slansky
University of Colorado Cancer Center
Clinical Cancer Research
University of Colorado Boulder
University of Colorado Denver
University of Colorado Anschutz Medical Campus
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Jordan et al. (Mon,) studied this question.
synapsesocial.com/papers/69dfeea035659245ec6152fc — DOI: https://doi.org/10.1158/1078-0432.ccr-20-1762