Interleukin-6 knockout significantly alleviated aging-related cardiac dysfunction, reversed macrophage differentiation imbalance, and protected against cardiomyocyte apoptosis in aging mice.
Cardiac aging and dysfunction (n=114)
Interleukin-6 (IL-6) knockout vs Wild-type (WT) mice
Cardiac dysfunction, macrophage differentiation, and cardiomyocyte apoptosis, p=<0.05
p-value: p=<0.05
. Furthermore, the mRNA expression of both aging markers and apoptosis-related markers was markedly inhibited by IL-6 KO. Our results suggest that aging can be significantly reversed by IL-6 KO and that the mechanisms of this effect are related to alleviation of Mø1/Mø2 imbalance and protection against apoptosis in cardiomyocytes.
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Yuan Wang
Wuhan University
Shan Zhu
Henan University of Traditional Chinese Medicine
Wen Wei
Wuhan University
Aging
Wuhan University
Renmin Hospital of Wuhan University
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Wang et al. (Sun,) conducted a other in Cardiac aging and dysfunction (n=114). Interleukin-6 (IL-6) knockout vs. Wild-type (WT) mice was evaluated on Cardiac dysfunction, macrophage differentiation, and cardiomyocyte apoptosis (p=<0.05). Interleukin-6 knockout significantly alleviated aging-related cardiac dysfunction, reversed macrophage differentiation imbalance, and protected against cardiomyocyte apoptosis in aging mice.
synapsesocial.com/papers/6a1c2cd6ea84844e355f8c81 — DOI: https://doi.org/10.18632/aging.103749