A combination of a Western diet and DOCA-induced hypertension in female Göttingen miniswine successfully generated a novel model of HFpEF characterized by elevated LV filling pressures and multiorgan comorbidities.
Does the combination of a Western diet and DOCA-induced hypertension recapitulate the multiorgan comorbid phenotype of HFpEF in female Göttingen minipigs?
The combination of a Western diet and DOCA-induced hypertension in Göttingen minipigs successfully creates a translationally relevant large animal model of HFpEF that integrates multiple clinical comorbidities.
Absolute Event Rate: 17.7% vs 9.5%
p-value: p=<0.001
A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt-induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.
Sharp et al. (2021) studied Heart Failure with Preserved Ejection Fraction (HFpEF) (n=11). Western diet and DOCA vs. Standard diet was evaluated on Left ventricular end-diastolic pressure (LVEDP) at 20 weeks (mm Hg) (p=<0.001). A combination of a Western diet and DOCA-induced hypertension in female Göttingen miniswine successfully generated a novel model of HFpEF characterized by elevated LV filling pressures and multiorgan comorbidities.