March 1, 2021
Renal Sympathetic Denervation in Patients With Heart Failure With Preserved Ejection Fraction
Structured PICO
Does Renal Sympathetic Denervation improve hemodynamic alterations and LV stiffness in patients with HFpEF?
P
Population
Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) and no-HF patients
I
Intervention
Renal Sympathetic Denervation (RDN)
C
Comparator
no-HF patients (for baseline comparison) and pre-RDN baseline
O
Outcome
Stroke volume index, vascular stiffness, and left ventricular (LV) stiffnesssurrogate
Renal sympathetic denervation may partly normalize hemodynamic alterations and LV stiffness in patients with HFpEF, suggesting a potential therapeutic role.
Abstract
Patients with HFpEF undergoing RDN showed increased stroke volume index, vascular, and LV stiffness as compared to no-HF patients. Following RDN those hemodynamic alterations and reduced systolic and diastolic LV stiffness were partly normalized, implying RDN might be a potential therapeutic strategy for arterial hypertension and HFpEF.
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Authors
K
Karl‐Patrik Kresoja
Interventional Cardiology
Karl‐Philipp Rommel
Interventional Cardiology
K
Karl Fengler
Interventional Cardiology
Journals
Circulation Heart Failure
Actions
Institutions
University Hospital Leipzig
Leipzig Heart Institute
Universitätsklinikum des Saarlandes
References and Citations
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