A short periostin isoform expressed on CPC-secreted exosomes promotes cardiomyocyte cell cycle-reentry and proliferation, whereas recombinant full-length periostin does not.
This study provides first evidence that a specific short periostin isoform on CPC-secreted exosomes can induce cardiomyocyte proliferation, highlighting a potential target for cardiac regeneration.
Our results show, for the first time, that CPC-secreted exosomes promote cardiomyocyte cell cycle-reentry via a short periostin isoform expressed on their surfaces, whereas recombinant full-length periostin does not. These findings highlight isoform-specific roles of periostin in cardiomyocyte proliferation.
Balbi et al. (2021) studied this question. A short periostin isoform expressed on CPC-secreted exosomes promotes cardiomyocyte cell cycle-reentry and proliferation, whereas recombinant full-length periostin does not.