May 19, 2021Open Access
Final Report of a Trial of Intensive versus Standard Blood-Pressure Control
Structured PICO
Does targeting a systolic blood pressure of less than 120 mm Hg reduce major adverse cardiovascular events and all-cause mortality in patients who were at increased cardiovascular risk?
P
Population
Patients who were at increased cardiovascular risk
I
Intervention
Targeting a systolic blood pressure of less than 120 mm Hg
C
Comparator
Targeting a systolic blood pressure of less than 140 mm Hg
O
Outcome
Major adverse cardiovascular eventshard clinical
Intensive blood pressure control targeting a systolic blood pressure of <120 mm Hg reduces major adverse cardiovascular events and all-cause mortality in high-risk patients compared to a standard <140 mm Hg target.
Abstract
Among patients who were at increased cardiovascular risk, targeting a systolic blood pressure of less than 120 mm Hg resulted in lower rates of major adverse cardiovascular events and lower all-cause mortality than targeting a systolic blood pressure of less than 140 mm Hg, both during receipt of the randomly assigned therapy and after the trial. Rates of some adverse events were higher in the intensive-treatment group. (Funded by the National Institutes of Health; SPRINT ClinicalTrials.gov number, NCT01206062.).
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Authors
Cora E. Lewis
Preventive Cardiology
Journals
New England Journal of Medicine
Actions
Institutions
National Heart Lung and Blood Institute
References and Citations
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