Premature ASCVD in adults aged 18-55 years was associated with a significantly higher risk of any cancer diagnosis compared to those without premature ASCVD (13.7% vs 3.9%; OR 2.08; 95% CI 1.72-2.50).
Cross-Sectional
Yes
Is premature ASCVD associated with a higher risk of cancer in young adults?
Premature ASCVD in young adults is associated with a twofold higher odds of a cancer diagnosis, highlighting the potential shared risk factors and the need for comprehensive preventive strategies.
Effect estimate: OR 2.08 (95% CI 1.72-2.50)
Absolute Event Rate: 13.7% vs 3.9%
p-value: p=< 0.01
AIM: The aim of this study was to investigate a possible association between atherosclerotic cardiovascular disease (ASCVD) and risk of cancer in young adults. METHODS: We utilized data from the Behavioral Risk Factor Surveillance System, a nationally representative US telephone-based survey to identify participants in the age group of 18-55 years who reported a history of ASCVD. These patients were defined as having premature ASCVD. Weighted multivariable logistic regression models were used to study the association between premature ASCVD and cancer including various cancer subtypes. RESULTS: Between 2016 and 2019, we identified 28 522 (3.3%) participants with a history of premature ASCVD. Compared with patients without premature ASCVD, individuals with premature ASCVD were more likely to be Black adults, have lower income, lower levels of education, reside in states without Medicaid expansion, have hypertension, diabetes mellitus, chronic kidney disease, obesity, and had delays in seeking medical care. Individuals with premature ASCVD were more likely to have been diagnosed with any form of cancer (13.7% vs 3.9%), and this association remained consistent in multivariable models (odds ratio, 95% confidence interval: 2.08 1.72-2.50, P < 0.01); this association was significant for head and neck (21.084.86-91.43, P < 0.01), genitourinary (18.64 3.69-94.24, P < 0.01), and breast cancer (3.96 1.51-10.35, P < 0.01). Furthermore, this association was consistent when results were stratified based on gender and race, and in sensitivity analysis using propensity score matching. CONCLUSION: Premature ASCVD is associated with a higher risk of cancer. These data have important implications for the design of strategies to prevent ASCVD and cancer in young adults.
Jain et al. (Tue,) conducted a cross-sectional in Premature atherosclerotic cardiovascular disease. Premature ASCVD vs. Patients without premature ASCVD was evaluated on Diagnosis of any form of cancer (OR 2.08, 95% CI 1.72-2.50, p=< 0.01). Premature ASCVD in adults aged 18-55 years was associated with a significantly higher risk of any cancer diagnosis compared to those without premature ASCVD (13.7% vs 3.9%; OR 2.08; 95% CI 1.72-2.50).