A higher waist-to-height ratio (≥ 0.5) was significantly associated with an increased risk of all-cause death (adjusted HR 1.91) in Chinese patients with heart failure with preserved ejection fraction.
Cohort (n=2,041)
No
Does a high waist-to-height ratio increase the risk of mortality in Chinese patients with HFpEF?
A high waist-to-height ratio (≥ 0.5) is an independent risk factor for all-cause mortality and heart failure rehospitalization in Chinese patients with HFpEF.
Hazard Ratio: 1.91 (95% CI 1.06–3.45)
Absolute Event Rate: 9.86% vs 5.56%
p-value: p=0.032
BACKGROUND: Abdominal obesity as a predominant comorbidity has played a key role in the incidence and worsening of heart failure with preserved ejection fraction (HFpEF), and waist-to-height ratio (WHtR) behaves better than waist circumference or body mass index in evaluating abdominal obesity. While the association between WHtR and all-cause death in Chinese patients with HFpEF remains unclear. METHODS: Patients with stable HFpEF (N = 2041) who presented to our hospital from January 2008 to July 2019 were divided into low-WHtR (< 0.5, N = 378) and high-WHtR (≥ 0.5, N = 1663). Multivariable Cox proportional-hazard models were used to examine the association of WHtR with all-cause death. RESULTS: The average age was 76.63 ± 11.44 years, and the mean follow-up was 4.53 years. During follow-up, 185 patients (9.06%) reached the primary outcome of all-cause death. As for the secondary outcome, 79 patients (3.87%) experienced cardiovascular death, 106 (5.19%) had non-cardiovascular death, and 94 (4.61%) had heart failure rehospitalization. After multivariable adjustment, a higher WHtR was significantly associated with the increased risks of all-cause death adjusted hazard ratios (HR) 1.91, 95% confidence interval (CI) 1.06-3.45, p = 0.032, cardiovascular death (adjusted HR 2.58; 95% CI 1.01-6.67, p = 0.048), and HF rehospitalization (adjusted HR 3.04; 95% CI 1.26-7.31, p = 0.013). CONCLUSIONS: Higher WHtR is an independent risk factor for all-cause death in Chinese patients with HFpEF.
Chen et al. (Fri,) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=2,041). High waist-to-height ratio (≥ 0.5) vs. Low waist-to-height ratio (< 0.5) was evaluated on All-cause death (HR 1.91, 95% CI 1.06-3.45, p=0.032). A higher waist-to-height ratio (≥ 0.5) was significantly associated with an increased risk of all-cause death (adjusted HR 1.91) in Chinese patients with heart failure with preserved ejection fraction.