What is the clinical evidence from this study?

Study design: Observational. Population: Acute myocardial infarction (AMI). Intervention: Female sex vs. Male sex. Primary outcome: Mortality rates and major adverse cardiovascular and cerebrovascular events (aOR 1.07 (2004) vs 1.11 (2015), 95% CI 1.04-1.09 vs 1.07-1.15, p=< 0.001).

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July 1, 2021Open Access

Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States

Q: What are the key findings of this study?

Female patients hospitalized for acute myocardial infarction experienced persistently higher mortality rates compared to men over a 12-year period (2004 aOR 1.07 vs 2015 aOR 1.11).

AMAndrija MatetićKeele University WSWarkaa ShamkhaniUniversity of Liverpool MRMuhammad RashidInterventional Cardiology

Key Result

Female patients hospitalized for acute myocardial infarction experienced persistently higher mortality rates compared to men over a 12-year period (2004 aOR 1.07 vs 2015 aOR 1.11).

Study Design

Type

Observational

Structured PICO

Do female patients experience worse clinical outcomes and lower receipt of invasive therapies after acute myocardial infarction compared with male patients over time?

Population

Patients with acute myocardial infarction (AMI) hospitalizations over 12 years (2004-2015) in the United States

Intervention

Female sex

Comparator

Male sex

Outcome

In-hospital outcomes including mortality rates, major adverse cardiovascular and cerebrovascular events, and receipt of invasive therapieshard clinical

Women continue to experience lower receipt of invasive therapies and higher in-hospital mortality rates after AMI compared to men, with no improvement in these disparities over a 12-year period.

Main Result

Effect estimate: aOR 1.07 (2004) vs 1.11 (2015) (95% CI 1.04-1.09 vs 1.07-1.15)

p-value: p=< 0.001

Abstract

BACKGROUND: Female patients have been shown to experience worse clinical outcomes after acute myocardial infarction (AMI) compared with male patients. However, it is unclear what trend these differences followed over time. METHODS: test was performed to examine the trend of management and in-hospital outcomes over the study period. RESULTS: < 0.001) and these rates have not narrowed over time (2004 vs 2015: aOR, 1.07 95% CI, 1.04-1.09 vs 1.11 [95% CI, 1.07-1.15), with similar observations recorded for major adverse cardiovascular and cerebrovascular events. CONCLUSIONS: In this temporal analysis of AMI hospitalizations over 12 years, we showed lower receipt of invasive therapies and higher mortality rates in women, with no change in temporal trends. There needs to be a systematic and consistent effort toward exploring these disparities to identify strategies to mitigate them.

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Cite This Study

Matetić et al. (Thu,) conducted a observational in Acute myocardial infarction (AMI). Female sex vs. Male sex was evaluated on Mortality rates and major adverse cardiovascular and cerebrovascular events (aOR 1.07 (2004) vs 1.11 (2015), 95% CI 1.04-1.09 vs 1.07-1.15, p=< 0.001). Female patients hospitalized for acute myocardial infarction experienced persistently higher mortality rates compared to men over a 12-year period (2004 aOR 1.07 vs 2015 aOR 1.11).

synapsesocial.com/papers/6a11e55f02d9c5b08421c186 https://doi.org/https://doi.org/10.1016/j.cjco.2021.06.012

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