High-intensity interval training significantly improved peak oxygen uptake compared to control in post-MI patients (MD 3.83 mL/kg/min; 95% CI 3.25-4.41; P<0.01).
Meta-Analysis (n=387)
Does high-intensity interval training (HIIT) improve peak oxygen uptake compared to moderate-intensity continuous training or routine physical activity in post-myocardial infarction patients?
High-intensity interval training significantly improves exercise capacity (peak VO2) in post-myocardial infarction patients without increasing the risk of adverse events compared to moderate-intensity training or routine activity.
Mean Difference: 3.83 (95% CI 3.25–4.41)
p-value: p=< 0.01
AIMS: Exercise-based cardiac rehabilitation has been recommended a treatment for patients with cardiovascular disease. Nevertheless, it remains controversial which exercise characteristics are most beneficial for post-myocardial infarction (MI) patients. We performed a systematic review and meta-analysis to investigate the effects of high-intensity interval training (HIIT) in these patients. METHODS AND RESULTS: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang Dataset (from the earliest date available to February 2021) for randomized controlled trials and cohort studies that evaluated the effects of HIIT on post-MI patients. Studies were selected according to inclusion and exclusion criteria. Data synthesis was performed with R software version 4.0.1. Eight studies met the study criteria, including 387 patients. Compared to the control group moderate-intensity continuous training (MICT) and/or routine physical activity, HIIT significantly improved peak oxygen uptake (peak VO2) mean difference = 3.83 mL/kg/min, 95% confidence interval (CI) (3.25, 4.41), P < 0.01. No significant difference in systolic and diastolic blood pressures, peak and resting heart rate, left ventricular ejection fraction, left ventricular end-diastolic volume, and the quality of life was found between HIIT group and control group. The duration of follow-up ranged from 6 to 12 weeks. The incidence of adverse events was similar between groups risk difference = 0.01, 95% CI (-0.02, 0.04), P = 0.53. CONCLUSION: Compared with MICT and routine physical activity, HIIT could significantly improve exercise capacity in post-MI patients, and appears to be safe.
Qin et al. (Fri,) conducted a meta-analysis in post-myocardial infarction (n=387). High-intensity interval training (HIIT) vs. Moderate-intensity continuous training (MICT) and/or routine physical activity was evaluated on peak oxygen uptake (peak VO2) (MD 3.83, 95% CI 3.25, 4.41, p=< 0.01). High-intensity interval training significantly improved peak oxygen uptake compared to control in post-MI patients (MD 3.83 mL/kg/min; 95% CI 3.25-4.41; P<0.01).