Obesity was associated with a significantly higher prevalence of raised C-reactive protein compared to non-obese patients (56.9% vs 47.9%) and correlated with more severe coronary artery disease.
Cross-Sectional (n=668)
No
Does obesity and elevated C-reactive protein associate with the severity of coronary artery disease in patients with ischemic heart disease?
Obesity is associated with raised C-reactive protein levels and more severe angiographic coronary artery disease in patients with ischemic heart disease.
Absolute Event Rate: 56.9% vs 47.9%
p-value: p=0.04
Background: Obesity is now becoming a global epidemic. It is most of the times associated with hypertension, diabetes mellitus (DM), metabolic syndrome and dyslipidemia which are known risk factors for coronary artery disease (CAD). Coronary arteriosclerosis comprises a series of inflammatory responses at cellular and molecular level, whose reactions are stronger in obese patients. The objective of this study was to observe the association of obesity and raised inflammatory markers with CAD. Method: This cross-sectional study was carried out in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka, Bangladesh, involving 668 patients of ischemic heart disease who underwent coronary angiography (CAG) from January 2017 to December 2017. Obesity was defined as body-mass index (BMI) ≥30.0 kg/m2. C-reactive protein (CRP) was measured as the inflammatory marker, and was considered as high if >10 mg/L. CAD was classified on the basis of CAG findings: insignificant if stenosis is 10 mg/L) and non-high CRP (≤10 mg/L) groups, however, DM, hypertension and dyslipidaemia were significantly more common in obese and high-CRP groups than in non-obese and non-high CRP groups. Raised CRP was significantly more common in obese than in non-obese patients (56.9% vs. 47.9%, p=0.04). Significant positive correlation was found between CRP and BMI (r=0.228; p=0.001). Triple-vessel CAD was found significantly more commonly in obese group than in non-obese group (29.3% vs 24.4%, p=0.04), whereas normal coronaries were more common in nonobese than in obese counterpart. Obesity, high CRP (>10 mg/L), DM, and high HbA1c (≥6.5%) were found significant predictors of severe CAD (p <0.5) in multivariate logistic regression analysis. Conclusion: Obesity is associated with raised inflammatory marker in patients with CAD, and a significant positive association exists between obesity and inflammation and CAD. Future studies are needed to explore the impact of type of obesity and inflammation on CAD. Bangladesh Heart Journal 2021; 36(1): 9-16
Ahmed et al. (Mon,) conducted a cross-sectional in Ischemic heart disease / Coronary artery disease (n=668). Obesity (BMI ≥30.0 kg/m2) vs. Non-obese (BMI <30.0 kg/m2) was evaluated on Raised C-reactive protein (>10 mg/L) (p=0.04). Obesity was associated with a significantly higher prevalence of raised C-reactive protein compared to non-obese patients (56.9% vs 47.9%) and correlated with more severe coronary artery disease.