LA booster strain ≤ 8% significantly increased the risk of new onset atrial fibrillation in patients with hypertrophic cardiomyopathy, with a hazard ratio of HR 3.69 versus those with strain > 8%.
Observational (n=238)
No
Does impaired left atrial strain assessed by CMR predict new onset atrial fibrillation in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, impaired left atrial booster and reservoir strain on CMR independently predict the development of new-onset atrial fibrillation, providing incremental prognostic value beyond LA size.
Effect estimate: HR 6.62 (95% CI 2.79-15.70)
Absolute Event Rate: 14% vs 0%
p-value: p=<0.001
LA strain components are impaired in HCM and, together with age, independently predicted the risk of new onset AF. Increasing age and phenotypic severity were associated with LA strain abnormalities. Our findings suggest that the routine assessment of LA strain components and consideration of age could augment LA size in predicting risk of AF, and potentially guide prophylactic anticoagulation use in HCM.
Raman et al. (Mon,) conducted a observational in hypertrophic cardiomyopathy (n=238). Left atrial booster and reservoir strain analysis via cardiovascular magnetic resonance vs. matched control subjects (n=20) was evaluated on new onset atrial fibrillation (HR 6.62, 95% CI 2.79-15.70, p=<0.001). LA booster strain ≤ 8% significantly increased the risk of new onset atrial fibrillation in patients with hypertrophic cardiomyopathy, with a hazard ratio of HR 3.69 versus those with strain > 8%.
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