Key result
LA booster strain ≤8% linked to ~269% higher risk of new AF in HCM.
Why the study?
Does impaired left atrial strain assessed by CMR predict new onset atrial fibrillation in patients with hypertrophic cardiomyopathy?
Observational (n=238)
No
Does impaired left atrial strain assessed by CMR predict new onset atrial fibrillation in patients with hypertrophic cardiomyopathy?
Answers are grounded in this paper and cite their sources.
In patients with hypertrophic cardiomyopathy, impaired left atrial booster and reservoir strain on CMR independently predict the development of new-onset atrial fibrillation, providing incremental prognostic value beyond LA size.
LA strain components are impaired in HCM and, together with age, independently predicted the risk of new onset AF. Increasing age and phenotypic severity were associated with LA strain abnormalities. Our findings suggest that the routine assessment of LA strain components and consideration of age could augment LA size in predicting risk of AF, and potentially guide prophylactic anticoagulation use in HCM.
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Raman et al. (2021) conducted an observational in hypertrophic cardiomyopathy (n=238). Left atrial booster and reservoir strain analysis via cardiovascular magnetic resonance vs. matched control subjects (n=20) was evaluated on new onset atrial fibrillation (HR 6.62, 95% CI 2.79-15.70, p=<0.001). LA booster strain ≤ 8% increased the risk of new onset atrial fibrillation in patients with hypertrophic cardiomyopathy, with a.69 versus those with strain > 8%.
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