What is the clinical evidence from this study?

Study design: Cohort. Population: Pediatric Hypertrophic Cardiomyopathy (n=326). Intervention: Left atrial strain derived from CMR Feature-Tracking vs. Normal controls. Primary outcome: Composite of sudden cardiac death (SCD) or equivalent events and heart failure-related events (HR 0.95, 95% CI 0.91-0.98, p=0.007).

What does this research mean for the field?

Left atrial reservoir and conduit strains derived from CMR Feature-Tracking are impaired in pediatric patients with hypertrophic cardiomyopathy and provide independent prognostic value for adverse clinical outcomes. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess left atrial myocardial function using cardiovascular magnetic resonance feature tracking and evaluate its prognostic value for adverse outcomes in pediatric hypertrophic cardiomyopathy.

September 14, 2026Journal of Cardiovascular Magnetic ResonanceOpen Access

CMR-derived left atrial reservoir and conduit strain independently predict adverse clinical outcomes in pediatric HCM.

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Why the study?

Does left atrial strain derived from CMR Feature-Tracking predict adverse clinical outcomes in pediatric patients with hypertrophic cardiomyopathy?

Population

284 pediatric patients with hypertrophic cardiomyopathy and 42 age- and sex-matched normal controls.

Comparison

Left atrial strain assessment derived from… vs Age- and sex-matched normal controls and…

Design

Cohort

Follow-up

median 62.8 months

Key result

Left atrial reservoir strain (HR 0.95; 95% CI 0.91-0.98; P=0.007) and conduit strain derived from CMR independently predicted adverse clinical outcomes in pediatric patients with HCM.

Authors

XCX Y Chen YTYun Tang XMXuan Ma

Discussion

Member takes

Overview

May support risk stratification in pediatric HCM; extends adult LA strain data but remains hypothesis-generating.

Key Points

To assess left atrial myocardial function using cardiovascular magnetic resonance feature tracking and evaluate its prognostic value for adverse outcomes in pediatric hypertrophic cardiomyopathy.
Retrospective analysis of 284 pediatric patients with hypertrophic cardiomyopathy (median age 15.0 years) and 42 age- and sex-matched controls who underwent cardiovascular magnetic resonance between January 2011 and December 2020.
Left atrial reservoir, conduit, and booster strains were quantified using feature tracking, with patients monitored over a median follow-up of 62.8 months for sudden cardiac death or heart failure events.
Pediatric patients with hypertrophic cardiomyopathy demonstrated significantly impaired left atrial reservoir and conduit strains compared to controls (both P<0.001), with no significant difference in booster strain.
Composite adverse outcomes occurred in 41 patients (14.4%), with multivariable Cox regression identifying reservoir strain (HR: 0.95, 95% CI: 0.91–0.98, P=0.007) and conduit strain (HR: 0.92, 95% CI: 0.87–0.97, P=0.002) as independent predictors.
Incorporating reservoir strain or conduit strain into standard clinical and imaging risk models significantly improved prognostic performance for both composite outcomes and sudden cardiac death events (all P<0.001).

Study Design

Type

Cohort (n=326)

Structured PICO

Does left atrial strain derived from CMR Feature-Tracking predict adverse clinical outcomes in pediatric patients with hypertrophic cardiomyopathy?

Population

284 pediatric patients with hypertrophic cardiomyopathy and 42 age- and sex-matched normal controls, followed for a median of 62.8 months.

Exposure

Left atrial (LA) strain assessment (reservoir, conduit, and booster strains) derived from Cardiovascular Magnetic Resonance Feature-Tracking (CMR-FT).

Comparator

Age- and sex-matched normal controls (for baseline comparison) and standard clinical/imaging risk models (for prognostic incremental value).

Outcome

Composite of sudden cardiac death (SCD) or equivalent events and heart failure-related events.hard clinical

Main Result

Hazard Ratio: 0.95 (95% CI 0.91–0.98)

p-value: p=0.007

Left atrial reservoir and conduit strains derived from CMR feature tracking provide independent and incremental prognostic value for predicting sudden cardiac death and heart failure events in pediatric patients with hypertrophic cardiomyopathy.

Cite This Study

Chen et al. (2026) conducted a cohort in Pediatric Hypertrophic Cardiomyopathy (n=326). Left atrial strain derived from CMR Feature-Tracking vs. Normal controls was evaluated on Composite of sudden cardiac death (SCD) or equivalent events and heart failure-related events (HR 0.95, 95% CI 0.91-0.98, p=0.007). Left atrial reservoir strain (HR 0.95; 95% CI 0.91-0.98; P=0.007) and conduit strain derived from CMR independently predicted adverse clinical outcomes in pediatric patients with HCM.

synapsesocial.com/papers/6aa7afef79e9260bc85aac6e https://doi.org/10.1016/j.jocmr.2026.102798

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September 14, 2026Journal of Cardiovascular Magnetic ResonanceOpen Access

CMR-derived left atrial reservoir and conduit strain independently predict adverse clinical outcomes in pediatric HCM.

View Full Paper

Ask AI

Bookmark

Why the study?

Does left atrial strain derived from CMR Feature-Tracking predict adverse clinical outcomes in pediatric patients with hypertrophic cardiomyopathy?

Population

284 pediatric patients with hypertrophic cardiomyopathy and 42 age- and sex-matched normal controls.

Comparison

Left atrial strain assessment derived from… vs Age- and sex-matched normal controls and…

Design

Cohort

Follow-up

median 62.8 months

Key result

Left atrial reservoir strain (HR 0.95; 95% CI 0.91-0.98; P=0.007) and conduit strain derived from CMR independently predicted adverse clinical outcomes in pediatric patients with HCM.

Authors

XCX Y Chen YTYun Tang XMXuan Ma

Discussion

Member takes

Overview

May support risk stratification in pediatric HCM; extends adult LA strain data but remains hypothesis-generating.

Key Points

To assess left atrial myocardial function using cardiovascular magnetic resonance feature tracking and evaluate its prognostic value for adverse outcomes in pediatric hypertrophic cardiomyopathy.
Retrospective analysis of 284 pediatric patients with hypertrophic cardiomyopathy (median age 15.0 years) and 42 age- and sex-matched controls who underwent cardiovascular magnetic resonance between January 2011 and December 2020.
Left atrial reservoir, conduit, and booster strains were quantified using feature tracking, with patients monitored over a median follow-up of 62.8 months for sudden cardiac death or heart failure events.
Pediatric patients with hypertrophic cardiomyopathy demonstrated significantly impaired left atrial reservoir and conduit strains compared to controls (both P<0.001), with no significant difference in booster strain.
Composite adverse outcomes occurred in 41 patients (14.4%), with multivariable Cox regression identifying reservoir strain (HR: 0.95, 95% CI: 0.91–0.98, P=0.007) and conduit strain (HR: 0.92, 95% CI: 0.87–0.97, P=0.002) as independent predictors.
Incorporating reservoir strain or conduit strain into standard clinical and imaging risk models significantly improved prognostic performance for both composite outcomes and sudden cardiac death events (all P<0.001).

Study Design

Type

Cohort (n=326)

Structured PICO

Does left atrial strain derived from CMR Feature-Tracking predict adverse clinical outcomes in pediatric patients with hypertrophic cardiomyopathy?

Population

284 pediatric patients with hypertrophic cardiomyopathy and 42 age- and sex-matched normal controls, followed for a median of 62.8 months.

Exposure

Left atrial (LA) strain assessment (reservoir, conduit, and booster strains) derived from Cardiovascular Magnetic Resonance Feature-Tracking (CMR-FT).

Comparator

Age- and sex-matched normal controls (for baseline comparison) and standard clinical/imaging risk models (for prognostic incremental value).

Outcome

Composite of sudden cardiac death (SCD) or equivalent events and heart failure-related events.hard clinical

Main Result

Hazard Ratio: 0.95 (95% CI 0.91–0.98)

p-value: p=0.007

Cite This Study

synapsesocial.com/papers/6aa7afef79e9260bc85aac6e https://doi.org/10.1016/j.jocmr.2026.102798

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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