Perioperative stroke and survival in coronary artery bypass grafting patients: a SWEDEHEART study

OBJECTIVES: Perioperative stroke is a severe complication of cardiac surgery. We assessed the incidence of stroke over time, the association between stroke and mortality and identified preoperative factors independently associated with perioperative stroke, in a large nationwide cardiac surgery population. METHODS: All patients who underwent coronary artery bypass grafting in Sweden 2006-2017 were included in a registry-based observational cohort study based on prospectively collected data. Multivariable logistic and Cox regression models were used to assess associations between perioperative stroke and mortality and to identify factors associated with stroke. The median follow-up was 6 years (range 0-12). RESULTS: There were 441 perioperative strokes in 36 898 patients. The mean incidence was 1.2% and decreased marginally over time adjusted odds ratio (OR) 0.97 per year (95% confidence interval 0.94-1.00), P = 0.035. Stroke patients had a higher overall mortality risk during follow-up adjusted hazard ratio 2.30 (2.00-2.64), P < 0.001, with the highest risk during the first 30 postoperative days adjusted hazard ratio (7.29 (5.58-9.54), P < 0.001. The strongest independent preoperative factors associated with stroke were prior cardiac surgery adjusted OR 2.89 (1.40-5.96), critical preoperative condition adjusted OR 2.55 (1.73-3.76), previous stroke adjusted OR 1.77 (1.35-2.33), preoperative angina requiring intravenous nitrates adjusted OR 1.67 (1.28-2.17), peripheral vascular disease OR 1.63 (1.25-2.13) and advanced age OR 1.05 (1.03-1.06) per year. CONCLUSIONS: The incidence of perioperative stroke after coronary artery bypass grafting has remained stable. Patients with perioperative stroke had a markedly higher adjusted risk of death early after surgery. The risk declined over time but remained higher during the entire follow-up period.