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Voice is abnormal in early-stage PD, progressively degrades in mid-advanced-stage and can be improved but not restored by L-Dopa. Lastly, machine learning allows tracking disease severity and quantifying the symptomatic effect of L-Dopa on voice parameters with previously unreported high accuracy, thus representing a potential new biomarker of PD.
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Antonio Suppa
Istituto Neurologico Mediterraneo
Giovanni Costantini
University of Rome Tor Vergata
Francesco Asci
Azienda Ospedaliera San Giovanni Addolorata
SHILAP Revista de lepidopterología
Frontiers in Neurology
Sapienza University of Rome
University of Pavia
University of Rome Tor Vergata
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Suppa et al. (Tue,) studied this question.
synapsesocial.com/papers/69db6776f7e0c66ced835a93 — DOI: https://doi.org/10.3389/fneur.2022.831428