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April 14, 2022Open Access

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

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Abstract

The results of this large-scale registry-based case-control study suggest that pathogenic variants in BRCA1 and BRCA2 were associated with the risk of 7 cancer types. These results indicate broader clinical relevance of BRCA1 and BRCA2 genetic testing.

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Authors

Yukihide Momozawa

RIKEN Center for Integrative Medical Sciences

Rumi Sasai

RIKEN Center for Integrative Medical Sciences

Yoshiaki Usui

RIKEN Center for Integrative Medical Sciences

Journals

JAMA Oncology

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Institutions

The University of Tokyo

Nagoya University

QIMR Berghofer Medical Research Institute

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Momozawa et al. (Thu,) studied this question.

synapsesocial.com/papers/69df3e7f6324afb55d5919e1 — DOI: https://doi.org/10.1001/jamaoncol.2022.0476

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Cancer Incidence in BRCA1 Mutation Carriers· 2002 · 1,088 citations
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Untitled· 2019 · 6 citations
Family History in Public Health Practice: A Genomic Tool for Disease Prevention and Health Promotion· 2010 · 310 citations
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers· 2017 · 2,846 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Cancer Incidence in BRCA1 Mutation Carriers· 2002 · 1,088 citations
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries· 2021 · 112,147 citations
Untitled· 2019 · 6 citations
Family History in Public Health Practice: A Genomic Tool for Disease Prevention and Health Promotion· 2010 · 310 citations
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers· 2017 · 2,846 citations

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider