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We consider the following class of problems: having observed a multivariate normal data vector y with unknown mean vector η, covariance matrix the identity, find an approximate confidence interval for ø = t(η), a real-valued function of η. A simple geometric construction is given which leads to highly accurate solutions. This construction shows that the standard approximation based on maximum likelihood theory, ø7plusmn;σz(α), can be quite misleading when ø is nonlinear in η. We discuss bootstrap-based confidence intervals which remove most of the error in the standard approximation, at the expense of considerably more calculation. The bootstrap intervals are invariant under transformation of both y and η, and so they automatically produce accurate solutions in problems which can be transformed to multivariate normality, without requiring knowledge of the normalizing transformation.
Bradley Efron (Mon,) studied this question.