Multiple sclerosis affects more than 2 million people worldwide and is currently incurable. A number of interventions to modify the course of multiple sclerosis have been developed that offer new insight into disease mechanisms.

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Reich et al. (Wed,) studied this question.

synapsesocial.com/papers/69d7621eef4aa71f97f3111c https://doi.org/https://doi.org/10.1056/nejmra1401483

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1Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination2000 · 3,342 citations
2TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group.1999 · 353 citations
3TNF neutralization in MS1999 · 1,011 citations
4Rejuvenation of Regeneration in the Aging Central Nervous System2012 · 645 citations
5Microglia: Scapegoat, Saboteur, or Something Else?2013 · 840 citations

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination2000 · 3,342 citations
2TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group.1999 · 353 citations
3TNF neutralization in MS1999 · 1,011 citations
4Rejuvenation of Regeneration in the Aging Central Nervous System2012 · 645 citations
5Microglia: Scapegoat, Saboteur, or Something Else?2013 · 840 citations