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January 10, 2018New England Journal of Medicine

Multiple Sclerosis

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Authors

DRDaniel S. ReichNational Institutes of HealthCLClaudia F. LucchinettiNorthwestern UniversityPeter A. CalabresiPeter A. CalabresiUniversity of Vermont

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Implication

Clinical review reveals evolving disease-modifying therapies in patients with multiple sclerosis, highlighting emerging insights into underlying disease mechanisms.

Key Points

  • To review the global impact of multiple sclerosis and examine how evolving therapeutic interventions clarify the biological mechanisms underlying the disease.
  • Assessed global epidemiological burden across populations exceeding two million affected individuals.
  • Synthesized evidence from clinical disease-modifying interventions that target multiple sclerosis progression.
  • Disease-modifying interventions substantially alter clinical progression, though curative therapies remain unavailable.
  • Therapeutic responses provide critical insight into the immunological and neurodegenerative mechanisms driving multiple sclerosis pathology.

Cite This Study

Reich et al. (2018) studied this question.

synapsesocial.com/papers/69d7621eef4aa71f97f3111chttps://doi.org/10.1056/nejmra1401483
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  1. 1Radiologically Isolated Syndrome: 5-Year Risk for an Initial Clinical Event2014 · 340 citations
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