Do clinical features and natural history differ between preadolescent and later childhood presentation of nonsyndromic hypertrophic cardiomyopathy?
Children with nonsyndromic hypertrophic cardiomyopathy (HCM), specifically comparing early-onset (preadolescent, <12 years) to those presenting later in childhood.
Patients presenting later in childhood (≥12 years)
Long-term outcomes including mortality and age at adverse eventshard clinical
Early-onset childhood HCM has similar long-term mortality to later childhood onset, but adverse events occur at a younger age.
Early-onset childhood HCM is associated with a comparable symptom burden and cardiac phenotype as in patients presenting later in childhood. Long-term outcomes including mortality did not differ by age of presentation, but patients presenting at younger than 12 years experienced adverse events at younger ages.
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Gabrielle Norrish
Pediatric Cardiology
Aoife Cleary
Great Ormond Street Hospital
Ella Field
Pediatric Cardiology
Journal of the American College of Cardiology
Työväentutkimus Vuosikirja
University College London
University of Helsinki
University of Liverpool
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Norrish et al. (Sun,) studied this question.
synapsesocial.com/papers/69cdb9b275204b754846c488 — DOI: https://doi.org/10.1016/j.jacc.2022.03.347