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The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its absence predicts a low risk of recurrence. The benefit of adjuvant chemotherapy for ctDNA-positive patients is not well understood.
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Jeanne Tie
Joshua D. Cohen
Kamel Lahouel
New England Journal of Medicine
Johns Hopkins University
Howard Hughes Medical Institute
The University of Melbourne
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Tie et al. (Sat,) studied this question.
www.synapsesocial.com/papers/69026c7729206953ba1494d1 — DOI: https://doi.org/10.1056/nejmoa2200075
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