Eight weeks of 50,000 IU weekly Vitamin D3 supplementation significantly increased serum 25(OH)D levels compared to placebo (p<0.001), but did not significantly improve muscle performance metrics.
RCT (n=29)
Double-blind
Drawing a number out of an envelope
No
Does Vitamin D3 supplementation improve serum 25(OH)D levels and muscle physical performance in physically active collegiate subjects?
Weekly supplementation with 50,000 IU of Vitamin D3 for eight weeks effectively corrected vitamin D deficiency in physically active young adults but did not significantly enhance muscle performance compared to placebo.
Effect estimate: partial η2 = 0.81
Absolute Event Rate: 78.24% vs 36.67%
p-value: p=<0.001
Objectives: This study aimed to determine if an eight-week supplementation of 50,000 IU of VitD3 will reverse deficiency in a physically active population. Patients or Other Participants: A total of 29 physically active collegiate subjects (age =23.21±1.52 yrs, weight =70.66±14.23 kg, height=171.18 ± 9.03 cm) volunteered to participate in the study. Intervention(s): Before completing pre-testing performance measures and beginning supplementation, venous blood samples to assess baseline serum 25(OH)D levels were collected from the cubital vein. Main Outcome Measures: Serum 25(OH)D levels and muscle performance metrics (bench press, vertical jump, and 40m sprint) were analyzed to determine differences between pre-test and post-test data of both the control and treatment groups, respectively. Results: A repeated measures ANOVA showed a significant increase in serum 25(OH)D levels after supplementation (p < .001) with a more prominent increase in the treatment group. These analyses indicate that there was no significant difference between the two treatment groups (VitD3 vs. placebo) at pre-treatment measurement, and post-treatment serum 25(OH)D status increased at a greater magnitude for Vitamin D (VitD) compared to the placebo group, who showed a relatively small change in serum 25(OH)D levels. Prior to D3 supplementation 19 of 29 total subjects (66%) had serum 25(OH)D concentrations considered to be deficient (<32 ng/ml). Conclusions: Total serum 25(OH)D concentration significantly increased and eliminated pathological deficiency in the supplementation group after eight weeks of supplementation with 50,000 IU of VitD3. Muscle performance metrics increased over the treatment period but were not significantly increased between treatment and control.
Ransone et al. (Sat,) conducted a rct in Vitamin D deficiency in physically active individuals (n=29). Vitamin D3 vs. Placebo was evaluated on Serum 25(OH)D levels (partial η2 = 0.81, p=<0.001). Eight weeks of 50,000 IU weekly Vitamin D3 supplementation significantly increased serum 25(OH)D levels compared to placebo (p<0.001), but did not significantly improve muscle performance metrics.
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