The HFA-PEFF score, but not the H2FPEF score, independently predicted all-cause mortality in HFpEF caused by cardiac amyloidosis (HR 1.51; 95% CI 1.16-1.95; p=0.002 per 1-point increase).
Cohort (n=304)
Do the HFA-PEFF and H2FPEF scores have diagnostic and prognostic value in patients with HFpEF caused by cardiac amyloidosis?
The HFA-PEFF score demonstrates superior diagnostic utility and independent prognostic value for all-cause mortality compared to the H2FPEF score in patients with HFpEF caused by cardiac amyloidosis.
Effect estimate: HR 1.51 (95% CI 1.16-1.95)
p-value: p=0.002
Aims The HFA‐PEFF and H 2 FPEF scores have been developed to diagnose heart failure with preserved ejection fraction (HFpEF), and hold prognostic value. Their value in patients with HFpEF caused by cardiac amyloidosis (CA) has never been investigated. Methods and results We evaluated the diagnostic and prognostic value of the HFA‐PEFF and H 2 FPEF scores in 304 patients from three cohorts with HFpEF caused by transthyretin CA ( n = 160, 53%) or immunoglobulin light‐chain CA ( n = 144, 47%). A diagnosis of HFpEF was more likely using the HFA‐PEFF score with 2 (1%), 71 (23%), and 231 (76%) patients ranked as having a low (0–1), intermediate (2–4), or high (5, 6) probability of HFpEF, respectively. Conversely, 36 (12%), 179 (59%) and 89 (29%) of patients ranked as having a low (0–1), intermediate (2–5), or high (6–9) probability of HFpEF using the H 2 FPEF score. During a median follow‐up of 19 months (interquartile range 8–40), 132 (43%) patients died. The HFA‐PEFF score, but not the H 2 FPEF score, predicted a high risk of all‐cause death which remained significant after adjustment for age, AL‐CA diagnosis, high‐sensitivity troponin T, N‐terminal pro‐B‐type natriuretic peptide, and echocardiographic parameters, including left ventricular global longitudinal strain, left ventricular diastolic function and right ventricular function (hazard ratio 1.51, 95% confidence interval 1.16–1.95, p = 0.002 for every 1‐point increase in HFA‐PEFF). Conclusions The HFA‐PEFF score has a higher diagnostic utility in HFpEF caused by CA and holds independent prognostic value for all‐cause mortality, while the H 2 FPEF score does not.
Tomasoni et al. (Wed,) conducted a cohort in heart failure and preserved ejection fraction caused by cardiac amyloidosis (n=304). HFA-PEFF score vs. H2FPEF score was evaluated on all-cause death (HR 1.51, 95% CI 1.16-1.95, p=0.002). The HFA-PEFF score, but not the H2FPEF score, independently predicted all-cause mortality in HFpEF caused by cardiac amyloidosis (HR 1.51; 95% CI 1.16-1.95; p=0.002 per 1-point increase).