Visceral adipose tissue volume was significantly associated with Type 2 Diabetes (OR 3.01; 95% CI 1.28-7.05; P<0.05), while epicardial fat was linked to impaired LV diastolic function.
Case-Control (n=92)
No
Are regional ectopic fat depots associated with adverse cardiac remodeling in patients with Type 2 Diabetes and matched controls?
Ectopic fat depots, particularly liver and epicardial fat, are associated with distinct patterns of adverse cardiac remodeling and diastolic dysfunction independently of type 2 diabetes.
Odds Ratio: 3.01 (95% CI 1.28–7.05)
p-value: p=<0.05
Background Different regional depots of fat have distinct metabolic properties and may relate differently to adverse cardiac remodeling. We sought to quantify regional depots of body fat and to investigate their relationship to cardiac structure and function in Type 2 Diabetes (T2D) and controls. Methods From the SCAPIS cohort in Linköping, Sweden, we recruited 92 subjects (35% female, mean age 59.5 ± 4.6 years): 46 with T2D and 46 matched controls. In addition to the core SCAPIS data collection, participants underwent a comprehensive magnetic resonance imaging examination at 1.5 T for assessment of left ventricular (LV) structure and function (end-diastolic volume, mass, concentricity, ejection fraction), as well as regional body composition (liver proton density fat fraction, visceral adipose tissue, abdominal subcutaneous adipose tissue, thigh muscle fat infiltration, fat tissue-free thigh muscle volume and epicardial adipose tissue). Results Compared to the control group, the T2D group had increased: visceral adipose tissue volume index ( P 0.001), liver fat percentage ( P 0.001), thigh muscle fat infiltration percentage ( P = 0.02), LV concentricity ( P 0.001) and LV E/e'-ratio ( P 0.001). In a multiple linear regression analysis, a negative association between liver fat percentage and LV mass (St Beta −0.23, P 0.05) as well as LV end-diastolic volume (St Beta −0.27, P 0.05) was found. Epicardial adipose tissue volume and abdominal subcutaneous adipose tissue volume index were the only parameters of fat associated with LV diastolic dysfunction (E/e'-ratio) (St Beta 0.24, P 0.05; St Beta 0.34, P 0.01, respectively). In a multivariate logistic regression analysis, only visceral adipose tissue volume index was significantly associated with T2D, with an odds ratio for T2D of 3.01 (95% CI 1.28–7.05, P 0.05) per L/m 2 increase in visceral adipose tissue volume. Conclusions Ectopic fat is predominantly associated with cardiac remodeling, independently of type 2 diabetes. Intriguingly, liver fat appears to be related to LV structure independently of VAT, while epicardial fat is linked to impaired LV diastolic function. Visceral fat is associated with T2D independently of liver fat and abdominal subcutaneous adipose tissue.
Edin et al. (Thu,) conducted a case-control in Type 2 Diabetes (n=92). Visceral adipose tissue volume vs. Lower visceral adipose tissue volume was evaluated on Type 2 Diabetes (per L/m2 increase in visceral adipose tissue volume) (OR 3.01, 95% CI 1.28-7.05, p=<0.05). Visceral adipose tissue volume was significantly associated with Type 2 Diabetes (OR 3.01; 95% CI 1.28-7.05; P<0.05), while epicardial fat was linked to impaired LV diastolic function.
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