Key result
Visceral adipose tissue volume was significantly associated with Type 2 Diabetes (OR 3.01; 95% CI 1.28-7.05; P<0.05), while epicardial fat was linked to impaired LV diastolic function.
Why the study?
Different regional fat depots possess distinct metabolic properties and may relate differently to adverse cardiac remodeling, prompting quantification and investigation of their relationship to cardiac structure and function in type 2 diabetes and controls.
Are regional ectopic fat depots associated with adverse cardiac remodeling in patients with Type 2 Diabetes and matched controls?
Population
92 subjects from the SCAPIS cohort in Linköping, Sweden including 46 with T2D and 46 matched controls
Comparison
Patients with T2D vs matched controls
Design
Case-control study
Authors
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Visceral fat-diabetes link is hypothesis-generating; should not yet change practice or guide interventions.
Case-Control (n=92)
No
Are regional ectopic fat depots associated with adverse cardiac remodeling in patients with Type 2 Diabetes and matched controls?
Odds Ratio: 3.01 (95% CI 1.28–7.05)
p-value: p=<0.05
Ectopic fat depots, particularly liver and epicardial fat, are associated with distinct patterns of adverse cardiac remodeling and diastolic dysfunction independently of type 2 diabetes.
Edin et al. (2022) conducted a case-control in Type 2 Diabetes (n=92). Visceral adipose tissue volume vs. Lower visceral adipose tissue volume was evaluated on Type 2 Diabetes (per L/m2 increase in visceral adipose tissue volume) (OR 3.01, 95% CI 1.28-7.05, p=<0.05). Visceral adipose tissue volume was significantly associated with Type 2 Diabetes (OR 3.01; 95% CI 1.28-7.05; P<0.05), while epicardial fat was linked to impaired LV diastolic function.
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