Key result
Diabetes, with or without obesity, was associated with increased myocardial (p=0.01) and hepatic (p=0.04) triglyceride content, and impaired myocardial energetics (p=0.04) compared to controls.
Why the study?
Do lean and obese patients with Type 2 diabetes exhibit increased ectopic and visceral fat deposition and cardiac/hepatic changes compared to normal-weight controls?
Cross-Sectional (n=54)
Do lean and obese patients with Type 2 diabetes exhibit increased ectopic and visceral fat deposition and cardiac/hepatic changes compared to normal-weight controls?
p-value: p=0.01
Diabetes is associated with significant abnormalities in cardiac structure, energetics, and steatosis regardless of BMI, though obese patients with T2D show a greater propensity for ectopic and visceral fat deposition.
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Lean T2D patients warrant targeted fat assessment in cardiac evaluation; leaves open whether this refines risk stratification or management.
Levelt et al. (2016) conducted a cross-sectional in Type 2 Diabetes (n=54). Type 2 Diabetes (with or without obesity) vs. Normal-weight controls was evaluated on Myocardial triglyceride content, hepatic triglyceride content, and myocardial energetics (p=0.01). Diabetes, with or without obesity, was associated with increased myocardial (p=0.01) and hepatic (p=0.04) triglyceride content, and impaired myocardial energetics (p=0.04) compared to controls.
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