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September 6, 2010European Journal of Clinical Investigation

Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution

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Key result

Type 2 diabetes in obese men was associated with significantly higher liver fat content (11.9%) compared to nondiabetic obese (5.2%, P<0.05) and normal-weight controls (1.6%, P<0.001).

Population

32 men aged 28-65 years with normal plasma triglyceride levels, comprising 13 diabetic obese in good…

Design

Cross-sectional

Authors

LBLutgarda BozzettoFederico II University HospitalAPAnna PrinsterInstitute of Biostructure and BioimagingMMMarcello ManciniInstitute of Biostructure and Bioimaging

Discussion

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Implication

Association between T2D and liver fat in obese men remains hypothesis-generating; prospective studies needed before any clinical implications.

Study Design

Type

Cross-Sectional (n=32)

Structured PICO

P
Population
32 men aged 28-65 years with normal plasma triglycerides, comprising 13 diabetic obese, 10 nondiabetic obese, and 9 normal-weight controls.
O
Outcome
Liver fat content measured by 1H-magnetic resonance spectroscopy, abdominal fat distribution by magnetic resonance imaging, and insulin sensitivity by hyperinsulinaemic euglycaemic clampsurrogate

Main Result

Absolute Event Rate: 11.9% vs 5.2%

p-value: p=<0.05

Type 2 diabetes is associated with increased liver fat accumulation independent of obesity and whole-body insulin resistance, potentially due to inadequate subcutaneous fat storing capacity.

Cite This Study

Bozzetto et al. (2010) conducted a cross-sectional in Obesity and Type 2 Diabetes Mellitus (n=32). Type 2 diabetes mellitus vs. Nondiabetic obesity and normal weight was evaluated on Liver fat content (p=<0.05). Type 2 diabetes in obese men was associated with significantly higher liver fat content (11.9%) compared to nondiabetic obese (5.2%, P<0.05) and normal-weight controls (1.6%, P<0.001).

synapsesocial.com/papers/6a79abbef8c4f08607023c4ahttps://doi.org/10.1111/j.1365-2362.2010.02372.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fatty Infiltration of the Liver1993 · 279 citations
  2. 2Decreased Expression of Adipogenic Genes in Obese Subjects with Type 2 Diabetes2006 · 171 citations
  3. 3Obesity-associated improvements in metabolic profile through expansion of adipose tissue2007 · 1,318 citations
  4. 4The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations2002 · 436 citations
  5. 5Abdominal adiposity and insulin resistance in obese men2002 · 289 citations