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November 20, 2012Socio-Environmental Systems ModelingOpen Access

Liver fat content is linked to inflammatory changes in subcutaneous adipose tissue in type 2 diabetes patients

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Population

27 obese patients with insulin-treated type 2 diabetes mellitus

Design

Cross-sectional

Authors

HJHenry JansenGVGerald VervoortMGMarinette van der Graaf

Discussion

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Overview

Suggests adipose inflammation as potential driver of liver fat in T2DM; hypothesis-generating, requires prospective confirmation.

Structured PICO

P
Population
27 obese patients with insulin-treated type 2 diabetes mellitus
O
Outcome
Associations between inflammatory features of the subcutaneous adipose tissue and liver fat contentsurrogate

Pro-inflammatory changes in subcutaneous adipose tissue are associated with increased liver fat content in obese patients with insulin-treated T2DM, suggesting adipose inflammation may drive liver fat accumulation.

Cite This Study

Jansen et al. (2012) studied this question.

synapsesocial.com/papers/6a760b09554f5a6e3e613b14https://doi.org/10.1111/cen.12105
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Also Consider

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  1. 1Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution2010 · 27 citations
  2. 2Hypoadiponectinemia Plays a Crucial Role in the Development of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus Independent of Visceral Adipose Tissue2007 · 37 citations
  3. 3PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular Events1997 · 390 citations
  4. 4The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue2011 · 112 citations
  5. 5Liver Fat Is Increased in Type 2 Diabetic Patients and Underestimated by Serum Alanine Aminotransferase Compared With Equally Obese Nondiabetic Subjects2007 · 198 citations