December 1, 2022Open Access
Interventricular Septum Thickness for the Prediction of Coronary Heart Disease and Myocardial Infarction in Hypertension Population: A Prospective Study
Key Result
Interventricular septum hypertrophy was associated with increased incidence of coronary heart disease (HR 1.155; 95% CI 1.155-2.861) and myocardial infarction (HR 2.410; 95% CI 1.303-4.458).
Study Design
Type
Cohort (n=10,349)
Structured PICO
Does interventricular septum hypertrophy predict the incidence of coronary heart disease and myocardial infarction in a general and hypertensive population?
P
Population
10,349 participants from the general population in Northeast China, including 4,801 with hypertension.
I
Intervention
Interventricular septum (IVS) hypertrophy detected by echocardiography
C
Comparator
Normal interventricular septum thickness (IVSd)
O
Outcome
Incidence of coronary heart disease (CHD) and myocardial infarction (MI)hard clinical
Interventricular septum hypertrophy detected by echocardiography is a significant predictor of incident coronary heart disease and myocardial infarction, suggesting its utility in early risk stratification.
Main Result
Effect estimate: HR 1.155 (CHD), HR 2.410 (MI) (95% CI 1.155-2.861 (CHD), 1.303-4.458 (MI))
p-value: p=0.01 (CHD), 0.005 (MI)
Abstract
The aim of the present study was to evaluate the prognostic value of interventricular septum thickness (IVSd) on the incidence of cardiovascular diseases. Based on the general population in Northeast China, 10,349 participants were successfully followed up for echocardiography over a median follow-up time of 4.66 years, among which 4801 were hypertensive. Coronary heart disease (CHD) and myocardial infarction (MI) incidence were followed up. Cox proportional hazards models were used to estimate the association of the baseline IVSd with adverse outcomes. IVS hypertrophy increased incident rates of CHD and MI compared with normal IVSd in the overall population and in the female sex-stratification group. In males, IVS hypertrophy had parallel increase rates of CHD (all p < 0.05). Kaplan−Meier analysis showed that IVS hypertrophy could predict CHD and MI incidence and CHD-free and MI-free survival. Multivariable Cox analysis revealed that IVS hypertrophy was correlated with CHD incidence (HR = 1.155, 95% CI = 1.155−2.861, p = 0.01) and MI incidence (HR = 2.410, 95% CI = 1.303−4.458, p = 0.005). In women, IVS hypertrophy was independently associated with CHD and MI incidence (all p < 0.05). Our prospective cohort study illustrated that IVS hypertrophy detected by echocardiography has a prognostic significance for CHD and MI. Therefore, the early detection of IVSd should be conducted to avoid adverse outcomes in further clinical practice.