Key points are not available for this paper at this time.
Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and validate these findings in the Amsterdam HELIUS cohort in 1,539 subjects. We identify association of thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup, and family Ruminococcaceae with depressive symptoms. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests that the gut microbiome composition may play a key role in depression.
Building similarity graph...
Analyzing shared references across papers
Loading...
Djawad Radjabzadeh
Jos A. Bosch
André G. Uitterlinden
Nature Communications
University of Oxford
University of Amsterdam
Erasmus University Rotterdam
Building similarity graph...
Analyzing shared references across papers
Loading...
Radjabzadeh et al. (Tue,) studied this question.
www.synapsesocial.com/papers/6a00625c7ac91c5d2a2d6a64 — DOI: https://doi.org/10.1038/s41467-022-34502-3