Does a Coronary Artery Disease Polygenic Risk Score (CAD PRS) improve risk prediction and identification for statin therapy in primary prevention patients?
Individuals in primary prevention, specifically younger individuals and patients with borderline and intermediate clinical risk
Coronary Artery Disease Polygenic Risk Score (CAD PRS)
Predictive ability for coronary artery disease risk
A CAD PRS has greater predictive utility in younger individuals and helps identify borderline or intermediate risk patients who would benefit from statin therapy in primary prevention.
Results of this cohort study suggest that the predictive ability of a CAD PRS was greater in younger individuals and can be used to better identify patients with borderline and intermediate clinical risk who should initiate statin therapy.
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Nicholas Marston
Preventive Cardiology
James P. Pirruccello
Preventive Cardiology
Giorgio Melloni
Brigham and Women's Hospital
JAMA Cardiology
Harvard University
University of Cambridge
University of California, San Francisco
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Marston et al. (Wed,) studied this question.
synapsesocial.com/papers/69d84b1ad56ca42147d1843a — DOI: https://doi.org/10.1001/jamacardio.2022.4466