Global longitudinal strain significantly improved from -13.8% at baseline to -15.8% at six months after ST-elevation myocardial infarction, while left ventricular ejection fraction remained unchanged.
Cohort (n=50)
No
Does CMR feature tracking strain improve from acute to chronic STEMI, and can it predict late gadolinium enhancement in patients with STEMI?
CMR feature tracking strain improves within six months after STEMI and can serve as an imaging biomarker to predict myocardial viability and late gadolinium enhancement.
Absolute Event Rate: -15.8% vs -13.8%
p-value: p=<0.001
Strain is an important imaging parameter to determine myocardial deformation. This study sought to 1) assess changes in left ventricular strain and ejection fraction (LVEF) from acute to chronic ST-elevation myocardial infarction (STEMI) and 2) analyze strain as a predictor of late gadolinium enhancement (LGE). 32 patients with STEMI and 18 controls prospectively underwent cardiac magnetic resonance imaging. Patients were scanned 8 Formula: see text 5 days and six months after infarction (± 1.4 months). Feature tracking was performed and LVEF was calculated. LGE was determined visually and quantitatively on short-axis images and myocardial segments were grouped according to the LGE pattern (negative, non-transmural and transmural). Global strain was impaired in patients compared to controls, but improved within six months after STEMI (longitudinal strain from -14 ± 4 to -16 ± 4%, p < 0.001; radial strain from 38 ± 11 to 42 ± 13%, p = 0.006; circumferential strain from -15 ± 4 to -16 ± 4%, p = 0.023). Patients with microvascular obstruction showed especially attenuated strain results. Regional strain persisted impaired in LGE-positive segments. Circumferential strain could best distinguish between LGE-negative and -positive segments (AUC 0.73- 0.77). Strain improves within six months after STEMI, but remains impaired in LGE-positive segments. Strain may serve as an imaging biomarker to analyze myocardial viability. Especially circumferential strain could predict LGE.
Erley et al. (Sat,) conducted a cohort in ST-elevation myocardial infarction (n=50). Cardiac magnetic resonance feature tracking vs. Baseline (8 ± 5 days post-infarction) was evaluated on Left ventricular global longitudinal strain (LV GLS) (p=<0.001). Global longitudinal strain significantly improved from -13.8% at baseline to -15.8% at six months after ST-elevation myocardial infarction, while left ventricular ejection fraction remained unchanged.