Does aficamten reduce LVOT gradients and improve biomarkers and symptoms in patients with obstructive hypertrophic cardiomyopathy?
Patients with obstructive hypertrophic cardiomyopathy (oHCM)
Aficamten
LVOT gradients, biomarkers, and symptomssurrogate
Aficamten, a sarcomere-targeted therapy, effectively reduces LVOT gradients and improves symptoms in patients with obstructive hypertrophic cardiomyopathy.
Aficamten resulted in substantial reductions in LVOT gradients with most patients experiencing improvement in biomarkers and symptoms. These results highlight the potential of sarcomere-targeted therapy for treatment of oHCM.
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Martin S. Maron
Ahmad Masri
Lubna Choudhury
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
Journal of the American College of Cardiology
University of Michigan
University of Oxford
University of Pennsylvania
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Maron et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69bf40cea1c38a784fa0cfff — DOI: https://doi.org/10.1016/j.jacc.2022.10.020
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