January 6, 2023Open Access

Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway

ZZZiyuan ZhouChinese Academy of Medical Sciences & Peking Union Medical College BWBaohong WangQingdao University XPXiaxia PanChinese Academy of Medical Sciences & Peking Union Medical College

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Abstract

In conclusion, IAA pretreatment can exacerbate D-GalN/LPS-induced ALF via probable Tlr2/NF-κB pathway involvement and ileac dysbiosis characterized by enriched gram-positive genus with potential pathogenesis. Microbial metabolites IAA may aggravate individual susceptibility to D-GalN/LPS-induced ALF. Further investigation of the underlying mechanism is needed, and intervention with indole derivatives and related commensal species should be undertaken with caution.

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