Specific subtype distribution with impact on prognosis of TP53 single-hit and double-hit events in AML and MDS

Key Points

• This research aims to investigate how specific TP53 events affect prognosis in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
• Examined subtype distribution of single-hit and double-hit TP53 events
• Analyzed survival outcomes in a cohort of patients with AML and MDS
• Utilized statistical methods for assessing prognosis based on TP53 alterations.
• Patients with double-hit TP53 events had a significantly worse prognosis compared to those with single-hit events (HR: 2.5, 95% CI: 1.5-4.0, p<0.01)
• Certain subtypes showed distinct survival outcomes, indicating specific prognostic value
• Overall findings suggest that TP53 event type should be considered in treatment planning.