Blood pressure variability is correlated with cognitive impairment and dementia independent of mean blood pressure levels.
Does blood pressure variability impact cognitive impairment and dementia?
This review highlights the independent correlation between blood pressure variability and cognitive decline, suggesting a potential target for optimizing blood pressure management to prevent dementia.
Dementia is the most common neurodegenerative disease in the aging population. Emerging evidence indicates that blood pressure (BP) variability is correlated with cognitive impairment and dementia independent of mean BP levels. The state-of-the-art review summarizes the latest evidence regarding the impact of BP variability on cognition in cognitively intact populations, patients with mild cognitive impairment, and different dementia types, focusing on the important confounding factors and new advances. This review also summarizes the potential mechanisms underlying the relationship between BP variability and cognitive impairment, and dementia, briefly discussing sex differences in the relationship. At last, current limitations and future perspectives are discussed to optimize BP management in preventing cognitive impairment and dementia.
Fen Sun (Mon,) conducted a review in Cognitive impairment and dementia. Blood pressure variability was evaluated on Cognitive impairment and dementia. Blood pressure variability is correlated with cognitive impairment and dementia independent of mean blood pressure levels.
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