Key result
Elevated blood pressure variability is linked to increased risk of cognitive impairment and dementia.
Why the study?
Emerging evidence indicates blood pressure variability correlates with cognitive impairment and dementia independent of mean blood pressure levels.
Does blood pressure variability predict cognitive impairment and dementia in aging populations?
Does blood pressure variability predict cognitive impairment and dementia in aging populations?
Blood pressure variability is a significant risk factor for cognitive decline and dementia, highlighting the importance of hemodynamic stability beyond just mean blood pressure control.
May aid cognitive risk assessment beyond mean BP; leaves open whether reducing variability prevents decline.
Dementia is the most common neurodegenerative disease in the aging population. Emerging evidence indicates that blood pressure (BP) variability is correlated with cognitive impairment and dementia independent of mean BP levels. The state-of-the-art review summarizes the latest evidence regarding the impact of BP variability on cognition in cognitively intact populations, patients with mild cognitive impairment, and different dementia types, focusing on the important confounding factors and new advances. This review also summarizes the potential mechanisms underlying the relationship between BP variability and cognitive impairment, and dementia, briefly discussing sex differences in the relationship. At last, current limitations and future perspectives are discussed to optimize BP management in preventing cognitive impairment and dementia.
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Fen Sun (2023) conducted a review in Cognitive impairment and dementia. Blood pressure variability vs. Stable blood pressure / lower blood pressure variability was evaluated on Cognitive decline and dementia. Elevated blood pressure variability is correlated with cognitive impairment and incident dementia, independent of mean blood pressure levels.
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