Key result
A 1 SD increase in systolic blood pressure variability was associated with increased odds of the presence or progression of white matter hyperintensities (OR 1.26; 95% CI 1.06-1.50).
Why the study?
It remained inconclusive whether blood pressure variability is associated with cerebral small vessel disease.
Does higher blood pressure variability increase the risk of presence or progression of cerebral small vessel disease markers in older adults?
Meta-Analysis (n=2,796)
Does higher blood pressure variability increase the risk of presence or progression of cerebral small vessel disease markers in older adults?
Effect estimate: OR 1.26 (95% CI 1.06-1.50)
Higher systolic blood pressure variability is associated with an increased risk of white matter hyperintensities, suggesting a potential target to prevent cerebral small vessel disease.
No takes yet. Share an insight, caveat, or question.
Targeting BP variability should not yet guide practice; leaves open whether reduction prevents white matter hyperintensities.
Ma et al. (2019) conducted a meta-analysis in Cerebral small vessel disease (n=2,796). Systolic blood pressure variability was evaluated on Presence or progression of white matter hyperintensities (OR 1.26, 95% CI 1.06-1.50). A 1 SD increase in systolic blood pressure variability was associated with increased odds of the presence or progression of white matter hyperintensities (OR 1.26; 95% CI 1.06-1.50).
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