Key result
Higher visit-to-visit BP variability links to ~18% higher all-cause dementia risk.
Why the study?
The study was conducted to investigate the association between visit-to-visit variability in blood pressure and the incidence of dementia and its subtypes in a general population.
Does higher visit-to-visit blood pressure variability increase the incidence of dementia in a general population without prior dementia?
Cohort (n=7,844,814)
Does higher visit-to-visit blood pressure variability increase the incidence of dementia in a general population without prior dementia?
Effect estimate: HR 1.18 (95% CI 1.16-1.19)
Higher visit-to-visit blood pressure variability is an independent predictor for developing dementia and its subtypes in the general population.
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BP variability associated with dementia risk in general population; hypothesis-generating for trials on variability reduction.
Yoo et al. (2020) conducted a cohort in Dementia (n=7,844,814). Blood pressure variability vs. No highest quartile for blood pressure variability was evaluated on All-cause dementia (HR 1.18, 95% CI 1.16-1.19). Higher visit-to-visit blood pressure variability increased the risk of all-cause dementia (HR 1.18; 95% CI 1.16-1.19 for highest quartile of both SBP and DBP vs no highest quartile).
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